Send to

Choose Destination
Nat Commun. 2017 Jan 17;8:14063. doi: 10.1038/ncomms14063.

Caloric restriction improves health and survival of rhesus monkeys.

Author information

Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224, USA.
Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53715, USA.
Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294, USA.
Geriatric Research Education and Clinical Center, Birmingham/Atlanta Veterans Administration Hospital, Birmingham, Alabama 35233, USA.
Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA.
GeroScience, Pylesville, Maryland 21323, USA.
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA.
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA.


Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact in nonhuman primates has been controversial. In the late 1980s two parallel studies were initiated to determine the effect of CR in rhesus monkeys. The University of Wisconsin study reported a significant positive impact of CR on survival, but the National Institute on Aging study detected no significant survival effect. Here we present a direct comparison of longitudinal data from both studies including survival, bodyweight, food intake, fasting glucose levels and age-related morbidity. We describe differences in study design that could contribute to differences in outcomes, and we report species specificity in the impact of CR in terms of optimal onset and diet. Taken together these data confirm that health benefits of CR are conserved in monkeys and suggest that CR mechanisms are likely translatable to human health.

[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

R.W. is a member of the board of LifeGen Technologies, a company focused on nutritional genomics. G.S.R. is Chief Executive Officer of GeroScience, Inc. and Vice President of Prolongevity Technologies. D.K.I. serves as Chief Scientific Officer for GeroScience, Inc., and Prolongevity Technologies, Inc. D.B.A. serves on the board of IKEA and has received consulting fees from multiple government, not for profit, and for profit organizations with interests in obesity and nutrition. None of these activities benefit directly from this research and no competing financial interests are declared. The remaining authors declare no competing financial interests.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center