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Nutr Cancer. 2017 Feb-Mar;69(2):229-237. doi: 10.1080/01635581.2017.1265131. Epub 2017 Jan 17.

Plasma 25-Hydroxyvitamin D3 Levels in Colorectal Cancer Patients and Associations with Physical Activity.

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a Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany.
b Huntsman Cancer Institute , Salt Lake City , Utah , USA.
c Division of Clinical Epidemiology , German Cancer Research Center (DKFZ) , Heidelberg Germany.
d Department of Cancer Epidemiology , H. Lee Moffitt Cancer Center and Research Institute , Tampa , Florida , USA.
e Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ) , Heidelberg , Germany.
f Fred Hutchinson Cancer Research Center , Seattle , Washington , USA.


Physical activity (PA) and vitamin D are thought to affect colorectal cancer prognosis. The present study investigates associations between 25(OH)D3 and PA in prospectively followed colorectal cancer patients in the ColoCare study. At 6, 12, and 24 mo after surgery, patients donated a blood sample, wore an accelerometer for 10 consecutive days, and completed a PA questionnaire. Plasma 25-hydroxyvitamin D3 (25(OH)D3) levels were measured by high-performance liquid chromatography. We tested associations using partial correlations and multivariate linear regression analysis, adjusted for season, age, and body mass index. A total of 137 assessments of 25(OH)D3 levels and PA were conducted (58 at 6 mo, 51 at 12 mo, and 28 at 24 mo). More than 60% of the patients were vitamin D-deficient (25(OH)D3 ≤20 ng/ml), independent of study time point. At 6-mo follow-up, accelerometry-based vigorous and moderate-to-vigorous PAs were positively associated with 25(OH)D3 levels (P = 0.04; P = 0.006,). PA together with season was a significant predictor of elevated 25(OH)D3 levels. Our results suggest that the majority of colorectal cancer patients may suffer from vitamin D deficiency. Engaging in PA may be an effective approach to increase their 25(OH)D3 levels.

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