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Muscle Nerve. 2017 Nov;56(5):919-924. doi: 10.1002/mus.25577. Epub 2017 Apr 11.

Electrodiagnosis of reversible conduction failure in Guillain-Barré syndrome.

Author information

1
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
2
Division of Neurology, University Medicine Cluster, National University Hospital, NUHS Tower Block, Level 10, 119228, Singapore.
3
Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
4
National Neuroscience Institute, Singapore.

Abstract

INTRODUCTION:

In this study we propose electrodiagnostic criteria for early reversible conduction failure (ERCF) in axonal Guillain-Barré syndrome (GBS) and apply them to a cohort of GBS patients.

METHODS:

Serial nerve conduction studies (NCS) were retrospectively analyzed in 82 GBS patients from 3 centers. The criteria for the presence of ERCF in a nerve were: (i) a 50% increase in amplitude of distal compound muscle action potentials or sensory nerve action potentials; or (ii) resolution of proximal motor conduction block with an accompanying decrease in distal latencies or compound muscle action potential duration or increase in conduction velocities.

RESULTS:

Of 82 patients from 3 centers, 37 (45%) had ERCF, 21 (26%) had a contrasting evolution pattern, and 8 (10%) had both. Sixteen patients did not show an amplitude increase of at least 50%.

CONCLUSION:

Our proposed criteria identified a group of patients with a characteristic evolution of NCS abnormality that is consistent with ERCF. Muscle Nerve 56: 919-924, 2017.

KEYWORDS:

Guillain-Barré syndrome; acute inflammatory demyelinating polyneuropathy; acute motor axonal neuropathy; conduction block; electrodiagnostic criteria; reversible conduction failure

PMID:
28093784
DOI:
10.1002/mus.25577
[Indexed for MEDLINE]

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