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Int J Biochem Cell Biol. 2017 Mar;84:58-74. doi: 10.1016/j.biocel.2017.01.005. Epub 2017 Jan 16.

Cinnamaldehyde induces apoptosis and reverses epithelial-mesenchymal transition through inhibition of Wnt/β-catenin pathway in non-small cell lung cancer.

Author information

1
The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of TCM, Nanjing, Jiangsu 210029, China.
2
Division of Membrane Dynamics, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
3
Liyang Hospital of Traditional Chinese Medicine, Liyang, Jiangsu 213300, China.
4
The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of TCM, Nanjing, Jiangsu 210029, China. Electronic address: WRP61@163.com.
5
The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of TCM, Nanjing, Jiangsu 210029, China. Electronic address: zxvery@126.com.

Abstract

Cinnamaldehyde, the main chemical component of the essential oil separated from the traditional herb Cinnamomum cassia, has been demonstrated to be an efficient cytotoxic agent against several human cancers. The present experiment showed that cinnamaldehyde dose-dependently depresses the proliferation of three types of NSCLC cells and induces cell apoptosis in vitro and in vivo. Moreover, cinnamaldehyde attenuated CoCl2-induced EMT and decreased matrix metalloprotease (MMP) family while the in vivo study showed the same trend. Mechanistically, cinnamaldehyde imitated the suppressive effect of XAV939 on cell motility and EMT which could be impaired by LiCl. Collectively, our research demonstrated for the first time that cinnamaldehyde is able to inhibit NSCLC cell growth by inducing apoptosis and reverse EMT through terminating Wnt/β-catenin pathway, which might supply further insight into cinnamaldehyde-mediated anti-tumor effect against NSCLC for better prognosis.

KEYWORDS:

Apoptosis; Cinnamaldehyde; EMT; NSCLC; Wnt/β-catenin pathway

PMID:
28093328
DOI:
10.1016/j.biocel.2017.01.005
[Indexed for MEDLINE]

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