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Trends Microbiol. 2017 May;25(5):362-374. doi: 10.1016/j.tim.2016.12.012. Epub 2017 Jan 11.

Ecology of the Oral Microbiome: Beyond Bacteria.

Author information

1
School of Dentistry, University of California, Los Angeles, CA 90095, USA.
2
School of Dentistry, University of California, Los Angeles, CA 90095, USA; C3 Jian, Inc. Marina del Rey, CA 90292, USA. Electronic address: wshi@dentistry.ucla.edu.
3
School of Dentistry, University of California, Los Angeles, CA 90095, USA. Electronic address: xhe@g.ucla.edu.

Abstract

Although great strides have been made in understanding the complex bacterial community inhabiting the human oral cavity, for a variety of (mainly technical) reasons the ecological contributions of oral fungi, viruses, phages, and the candidate phyla radiation (CPR) group of ultrasmall bacteria have remained understudied. Several recent reports have illustrated the diversity and importance of these organisms in the oral cavity, while TM7x and Candida albicans have served as crucial paradigms for CPR species and oral fungi, respectively. A comprehensive understanding of the oral microbiota and its influence on host health and disease will require a holistic view that emphasizes interactions among different residents within the oral community, as well as their interaction with the host.

KEYWORDS:

Candidate phyla radiation; Fungi; Meta-omics; Oral microbiome; Phage

PMID:
28089325
PMCID:
PMC5687246
DOI:
10.1016/j.tim.2016.12.012
[Indexed for MEDLINE]
Free PMC Article

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