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Brain Cogn. 2017 Apr;113:10-22. doi: 10.1016/j.bandc.2017.01.003. Epub 2017 Jan 11.

Verbal and musical short-term memory: Variety of auditory disorders after stroke.

Author information

1
INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Auditory Cognition and Psychoacoustics Team, Lyon F-69000, France; University Lyon 1, Villeurbanne F-69000, France; Stroke Department, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Bron F-69000, France. Electronic address: cat.hirel@gmail.com.
2
University Lyon 1, Villeurbanne F-69000, France; Stroke Department, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Bron F-69000, France; CREATIS, CNRS, UMR5220, INSERM, U1044, University Lyon 1, F-69000, France.
3
INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Auditory Cognition and Psychoacoustics Team, Lyon F-69000, France; University Lyon 1, Villeurbanne F-69000, France.
4
University Lyon 1, Villeurbanne F-69000, France; CREATIS, CNRS, UMR5220, INSERM, U1044, University Lyon 1, F-69000, France.
5
INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; University Lyon 1, Villeurbanne F-69000, France.
6
CERMEP, MEG Department, Bron F-69000, France.
7
INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; University Lyon 1, Villeurbanne F-69000, France; Stroke Department, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Bron F-69000, France.
8
CNRS, UMR5292, Lyon Neuroscience Research Center, Auditory Cognition and Psychoacoustics Team, Lyon F-69000, France; University Lyon 1, Villeurbanne F-69000, France.

Abstract

Auditory cognitive deficits after stroke may concern language and/or music processing, resulting in aphasia and/or amusia. The aim of the present study was to assess the potential deficits of auditory short-term memory for verbal and musical material after stroke and their underlying cerebral correlates with a Voxel-based Lesion Symptom Mapping approach (VLSM). Patients with an ischemic stroke in the right (N=10) or left (N=10) middle cerebral artery territory and matched control participants (N=14) were tested with a detailed neuropsychological assessment including global cognitive functions, music perception and language tasks. All participants then performed verbal and musical auditory short-term memory (STM) tasks that were implemented in the same way for both materials. Participants had to indicate whether series of four words or four tones presented in pairs, were the same or different. To detect domain-general STM deficits, they also had to perform a visual STM task. Behavioral results showed that patients had lower performance for the STM tasks in comparison with control participants, regardless of the material (words, tones, visual) and the lesion side. The individual patient data showed a double dissociation between some patients exhibiting verbal deficits without musical deficits or the reverse. Exploratory VLSM analyses suggested that dorsal pathways are involved in verbal (phonetic), musical (melodic), and visual STM, while the ventral auditory pathway is involved in musical STM.

KEYWORDS:

Amusia; Aphasia; Dual stream model; MRI; VLSM

PMID:
28088063
DOI:
10.1016/j.bandc.2017.01.003
[Indexed for MEDLINE]

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