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J Adolesc Health. 2017 Apr;60(4):455-459. doi: 10.1016/j.jadohealth.2016.11.005. Epub 2017 Jan 11.

Assessment of Sex Differences in Body Composition Among Adolescents With Anorexia Nervosa.

Author information

1
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California; Department of Pediatrics, Division of Adolescent and Young Adult Medicine, University of California, San Francisco, San Francisco, California. Electronic address: jasonmnagata@gmail.com.
2
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
3
Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
4
Department of Psychiatry, University of California, San Francisco, San Francisco, California.

Abstract

PURPOSE:

To compare deficits in fat mass (FM) and lean body mass (LM) among male and female adolescents with anorexia nervosa (AN) and to identify other covariates associated with body composition.

METHODS:

We retrospectively reviewed electronic medical records of all subjects aged 9-20 years with a Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition diagnosis of AN and dual-energy x-ray absorptiometry scans after initial evaluation at Stanford between March 1997 and February 2011. From the dual-energy x-ray absorptiometry scans, LM and FM results were converted to age-, height-, sex-, and race-specific Z-scores for age using the National Health and Nutrition Examination Survey reference data.

RESULTS:

A total of 16 boys and 119 girls with AN met eligibility criteria. The FM Z-score in girls with AN (-3.24 ± 1.50) was significantly lower than that in boys with AN (-2.41 ± .96) in unadjusted models (p = .007). LM was reduced in both girls and boys with AN, but there was no significant sex difference in LM Z-scores. In multivariate models, lower percentage median body mass index was significantly associated with lower FM Z-scores (β = .08, p < .0001) and lower LM Z-score (β = .03, p = .0002), whereas lower whole body bone mineral content Z-score was significantly associated with lower LM Z-score (β = .21, p = .0006).

CONCLUSIONS:

FM deficits in girls were significantly greater than those in boys with AN in unadjusted models; however, the degree of malnutrition appeared to be the primary factor accounting for this difference. There were no significant sex differences in FM or LM in adjusted models.

KEYWORDS:

Anorexia nervosa; Body composition; Dual-energy x-ray absorptiometry; Eating disorders; Females; Males; Sex differences

PMID:
28087266
PMCID:
PMC6402565
DOI:
10.1016/j.jadohealth.2016.11.005
[Indexed for MEDLINE]
Free PMC Article

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