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Gynecol Oncol. 2017 Apr;145(1):32-36. doi: 10.1016/j.ygyno.2016.12.023. Epub 2017 Jan 10.

Contribution of age to clinical trial enrollment and tolerance with ovarian cancer.

Author information

1
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: Jessica-gillen@ouhsc.edu.
2
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: Camille-gunderson@ouhsc.edu.
3
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: molly-greenwade@ouhsc.edu.
4
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: michelle-rowland@ouhsc.edu.
5
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: Rachel-ruskin@ouhsc.edu.
6
Department of Biostatistics and Epidemiology, University of Oklahoma, Oklahoma City, OK, United States. Electronic address: kai-ding@ouhsc.edu.
7
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: alia-crim@ouhsc.edu.
8
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: adam.waltermd@promedica.org.
9
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: Emily-white@ouhsc.edu.
10
Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: Kathleen-moore@ouhsc.edu.

Abstract

INTRODUCTION:

Increasing age has been correlated with shorter survival in ovarian cancer patients, a finding attributed to diminished tolerance of standard therapy. Elderly patients, however, are less likely to enroll on clinical trials; thus, limited data exists to evaluate their response to front line treatment. This study describes how elderly patients on trial fared, with respect to toxicity and response, compared to younger women.

METHODS:

A retrospective cohort study was performed of ovarian cancer patients enrolled in front line chemotherapy trials at our institution between 2000 and 2013. Patients were dichotomized by age: <70 and ≥70years. Clinical, pathologic, and treatment characteristics were recorded and analyzed using SAS version 9.3.

RESULTS:

336 patients were enrolled. Of these, 79 (23.5%) were ≥70yrs. Demographics were similar between the two groups. Compared to patients <70, those ≥70 completed a comparable number of chemotherapy cycles (p=0.16) and had similar numbers of dose modifications (p=0.40) and delays (p=0.26). Both hematologic and non-hematologic toxicities occurred at similar rates as well. Age≥70 (HR 1.8, 95% CI 1.27-2.54, p=0.0009), stage III/IV (HR 3.44, 95% CI 1.08-10.95, p=0.036), and residual disease (HR 2.63, 95% CI 1.82-3.78, p<0.0001) were independently predictive of shorter overall survival.

CONCLUSION:

Our data continues to support reports of shorter survival for older women with ovarian cancer. With physician bias removed and similar chemotherapy tolerance noted, our study suggests that inherent tumor biology may be a significant contributor. Further research is needed to identify the mechanisms which contribute to the inequality that age imposes on outcomes.

KEYWORDS:

Chemotherapy tolerance; Older women; Ovarian cancer

PMID:
28087143
DOI:
10.1016/j.ygyno.2016.12.023
[Indexed for MEDLINE]

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