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Oncotarget. 2017 Feb 14;8(7):11621-11628. doi: 10.18632/oncotarget.14598.

Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal.

Author information

1
Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
2
Department of Nursing, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
3
Traffic Police Department, Jinan Public Security Bureau, Jinan 250021, Shandong, P. R. China.
4
Scientific Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.

Abstract

The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7) expression. In LPS-challenged mice and Caco-2 cells, matrine alleviated LPS-induced inflammation and oxidative stress via downregulating pro-inflammatory cytokines (IL-1β and IL-17) and malondialdehyde (MDA) production. CCR7-siRNA transfection blocked the protective effects of matrine on LPS-induced inflammation and oxidative stress and exacerbated LPS caused injury. In conclusion, matrine alleviates LPS-induced intestinal inflammation and oxidative stress in mice and Caco-2 cells, which may be associated with CCR7 signal.

KEYWORDS:

CCR7; LPS; inflammation; matrine; oxidative stress

PMID:
28086227
PMCID:
PMC5355291
DOI:
10.18632/oncotarget.14598
[Indexed for MEDLINE]
Free PMC Article

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