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Cortex. 2017 Mar;88:98-105. doi: 10.1016/j.cortex.2016.12.016. Epub 2016 Dec 24.

Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife.

Author information

1
Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, UK; Department of Experimental Psychology, University of Oxford, Oxford, UK. Electronic address: nahid.zokaei@psy.ox.ac.uk.
2
Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
3
Department of Experimental Psychology, University of Oxford, Oxford, UK.
4
Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Headington, Oxford, UK; NIHR Oxford Biomedical Research Centre, ORH Trust, Oxford, Churchill Hospital, Oxford, UK.
5
Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, UK; Department of Experimental Psychology, University of Oxford, Oxford, UK.
6
Department of Experimental Psychology, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Abstract

Short-term memory in middle-aged individuals with different APOE alleles was examined using a recently developed task which is sensitive to medial temporal lobe (MTL) damage. Individuals (age-range: 40-51 years) with ε3/ε3, ε3/ε4 and ε4/ε4 APOE genotypes (N = 60) performed a delayed estimation task with a sensitive continuous measure of report. The paradigm allowed us to measure memory for items and their locations, as well as maintenance of identity-location feature binding in memory. There was a significant gene-dosage dependent effect of the ε4 allele on performance: memory decay or forgetting was slower in ε4 carriers, as measured by localization error and after controlling for misbinding errors. Furthermore ε4 carriers made less misbinding errors. These findings were specific to male carriers only. Thus, male ε4 carriers are at a behavioral advantage in midlife on a sensitive task of short-term memory. The results would be consistent with an antagonistic pleiotropy hypothesis and hightight the interaction of gender on the influence of APOE in cognition.

KEYWORDS:

Alzheimer's disease; ApoE; Binding; Working memory

PMID:
28086184
PMCID:
PMC5333781
DOI:
10.1016/j.cortex.2016.12.016
[Indexed for MEDLINE]
Free PMC Article

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