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Cell. 2017 Jan 12;168(1-2):328-328.e1. doi: 10.1016/j.cell.2016.12.038. Epub 2017 Jan 12.

SnapShot: Class 2 CRISPR-Cas Systems.

Author information

1
National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA.
2
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Class 2 CRISPR-Cas systems are characterized by effector modules consisting of single, large, multidomain proteins that appear to have been derived from mobile genetic elements. Some Class 2 effector proteins, such as Cas9 and Cas12a (Cpf1), have been successfully repurposed for genome engineering.

PMID:
28086097
DOI:
10.1016/j.cell.2016.12.038
[Indexed for MEDLINE]
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