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Molecules. 2017 Jan 11;22(1). pii: E108. doi: 10.3390/molecules22010108.

Antioxidant and Anti-Osteoporotic Activities of Aromatic Compounds and Sterols from Hericium erinaceum.

Author information

1
Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Korea. liwei1986@kiom.re.kr.
2
Department of Food and Nutrition, Hannam University, Daejeon 34430, Korea. shlee@hnu.ac.kr.
3
Department of Food and Nutrition, Hannam University, Daejeon 34430, Korea. haedong@hnu.ac.kr.
4
Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Korea. jyma@kiom.re.kr.
5
College of Pharmacy, Chungnam National University, Daejeon 34134, Korea. yhk@cnu.ac.kr.

Abstract

Hericium erinaceum, commonly called lion's mane mushroom, is a traditional edible mushroom widely used in culinary applications and herbal medicines in East Asian countries. In this study, a new sterol, cerevisterol 6-cinnamate (6), was isolated from the fruiting bodies of H. erinaceum together with five aromatic compounds 1-5 and five sterols 7-11. The chemical structures of these compounds were elucidated using chemical and physical methods and comparison of HRESIMS, ¹D-NMR (¹H, 13C, and DEPT) and 2D-NMR (COSY, HMQC, HMBC, and NOESY) spectra with previously reported data. The antioxidant and anti-osteoporotic activities of extracts and the isolated compounds 1-11 were investigated. All compounds exhibited peroxyl radical-scavenging capacity but only compounds 1, 3, and 4 showed potent reducing capacity. Moreover, compounds 1, 2, 4, and 5 showed moderate effects on cellular antioxidant activity and inhibited the receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastic differentiation. These results suggested that H. erinaceum could be utilized in the development of natural antioxidant and anti-osteoporotic nutraceuticals and functional foods.

KEYWORDS:

Hericium erinaceum; anti-osteoporosis; antioxidant; aromatic compound; hericiaceae; sterol

PMID:
28085076
DOI:
10.3390/molecules22010108
[Indexed for MEDLINE]
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