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Hum Brain Mapp. 2017 Mar;38(3):1702-1715. doi: 10.1002/hbm.23499. Epub 2017 Jan 13.

Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment.

Author information

1
Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, United Kingdom.
2
Interdisciplinary Computing and Complex BioSystems (ICOS) research group, School of Computing Science, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom.
3
Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, CB2 7EF, United Kingdom.
4
Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, United Kingdom.
5
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
6
School of Medicine and Menzies Health Institute Queensland, Griffith University, QLD, 4222, Australia.
7
Department of Psychiatry, University of Cambridge, Cambridge, CB2 0QC, United Kingdom.
8
John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, CB2 0PY, United Kingdom.
9
Department of Nuclear Medicine, Institute of Clinical Medicine, Aarhus University, Aarhus C, Denmark.

Abstract

Mild cognitive impairment (MCI) is prevalent in 15%-40% of Parkinson's disease (PD) patients at diagnosis. In this investigation, we study brain intra- and inter-network alterations in resting state functional magnetic resonance imaging (rs-fMRI) in recently diagnosed PD patients and characterise them as either cognitive normal (PD-NC) or with MCI (PD-MCI). Patients were divided into two groups, PD-NC (N = 62) and PD-MCI (N = 37) and for comparison, healthy controls (HC, N = 30) were also included. Intra- and inter-network connectivity were investigated from participants' rs-fMRIs in 26 resting state networks (RSNs). Intra-network differences were found between both patient groups and HCs for networks associated with motor control (motor cortex), spatial attention and visual perception. When comparing both PD-NC and PD-MCI, intra-network alterations were found in RSNs related to attention, executive function and motor control (cerebellum). The inter-network analysis revealed a hyper-synchronisation between the basal ganglia network and the motor cortex in PD-NC compared with HCs. When both patient groups were compared, intra-network alterations in RSNs related to attention, motor control, visual perception and executive function were found. We also detected disease-driven negative synchronisations and synchronisation shifts from positive to negative and vice versa in both patient groups compared with HCs. The hyper-synchronisation between basal ganglia and motor cortical RSNs in PD and its synchronisation shift from negative to positive compared with HCs, suggest a compensatory response to basal dysfunction and altered basal-cortical motor control in the resting state brain of PD patients. Hum Brain Mapp 38:1702-1715, 2017.

KEYWORDS:

FSL-Nets; Lewy body disease; brain connectivity; fMRI; networks

PMID:
28084651
DOI:
10.1002/hbm.23499
[Indexed for MEDLINE]

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