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Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600585. Epub 2017 Mar 20.

Neoagarotetraose protects mice against intense exercise-induced fatigue damage by modulating gut microbial composition and function.

Author information

1
College of Food Science and Engineering, Ocean University of China, Qingdao, China.
2
Animal Genomics and Improvement Laboratory, United States Department of Agriculture, Agriculture Research Service (USDA-ARS), Beltsville, MD, USA.

Abstract

SCOPE:

Exhaustive exercise stress has emerged as an important health issue, and gastrointestinal problems are a common concern during intense exercise. In this study, we investigated the potential antifatigue effects of neoagarotetraose (NAT) in mice under intense exercise stress.

MATERIALS AND METHODS:

Exhaustive exercise stress significantly weakened several physiological and physical parameters of the mice, including decreased food intake, reduced body weight, and impaired integrity of the intestinal epithelial barrier. Our data showed that a 16-day NAT treatment resulted in a profound change in microbiome composition, which subsequently led to widespread shifts in the functional potential of the gut microbiome. Furthermore, NAT administration significantly increased the fecal concentration of total short-chain fatty acids (p < 0.01).

CONCLUSION:

Together, our findings suggest that NAT may protect mice against intense exercise-induced fatigue and provide insights into the mechanisms of NAT as a potential prebiotic.

KEYWORDS:

16S rRNA; Gut microbiota; Metagenome; NAT; SCFAs

PMID:
28083922
DOI:
10.1002/mnfr.201600585
[Indexed for MEDLINE]

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