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Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1033-1041. doi: 10.1007/s00259-017-3614-7. Epub 2017 Jan 12.

Neural correlates of the popular music phenomenon: evidence from functional MRI and PET imaging.

Chen Q1,2,3,4,5, Zhang Y2,3,4,5, Hou H2,3,4,5, Du F2,3,4,5, Wu S2,3,4,5, Chen L2,3,4,5, Shen Y2,3,4,5, Chao F2,3,4,5, Chung JK6, Zhang H2,3,4,5, Tian M7,8,9,10.

Author information

1
Department of Psychiatry, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
2
Zhejiang University Medical PET Center, Hangzhou, China.
3
Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, China.
4
Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China.
5
Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.
6
Department of Nuclear Medicine, Seoul National University Hospital, Seoul, South Korea.
7
Zhejiang University Medical PET Center, Hangzhou, China. meitian@zju.edu.cn.
8
Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, China. meitian@zju.edu.cn.
9
Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China. meitian@zju.edu.cn.
10
Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China. meitian@zju.edu.cn.

Abstract

PURPOSE:

Music can induce different emotions. However, its neural mechanism remains unknown. The aim of this study was to use functional magnetic resonance imaging (fMRI) and position emission tomography (PET) imaging for mapping of neural changes under the most popular music in healthy volunteers.

METHODS:

Blood-oxygen-level-dependent (BOLD) fMRI and monoamine receptor PET imaging with 11C-N-methylspiperone (11C-NMSP) were conducted under the popular music Gangnam Style and light music A Comme Amour in healthy subjects. PET and fMRI images were analyzed by using the Statistical Parametric Mapping software (SPM).

RESULTS:

Significantly increased fMRI BOLD signals were found in the bilateral superior temporal cortices, left cerebellum, left putamen and right thalamus cortex. Monoamine receptor availability was increased significantly in the left superior temporal gyrus and left putamen, but decreased in the bilateral superior occipital cortices under the Gangnam Style compared with the light music condition. Significant positive correlation was found between 11C-NMSP binding and fMRI BOLD signals in the left temporal cortex. Furthermore, increased 11C-NMSP binding in the left putamen was positively correlated with the mood arousal level score under the Gangnam Style condition.

CONCLUSION:

Popular music Gangnam Style can arouse pleasure experience and strong emotional response. The left putamen is positively correlated with the mood arousal level score under the Gangnam Style condition. Our results revealed characteristic patterns of brain activity associated with Gangnam Style, and may also provide more general insights into the music-induced emotional processing.

KEYWORDS:

Brain function; Functional magnetic resonance imaging (fMRI); Monoamine receptor; Position emission tomography (PET)

PMID:
28083689
DOI:
10.1007/s00259-017-3614-7
[Indexed for MEDLINE]

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