Format

Send to

Choose Destination
Biomed Environ Sci. 2016 Dec;29(12):858-867. doi: 10.3967/bes2016.115.

Effect of Low Level Subchronic Microwave Radiation on Rat Brain.

Author information

1
Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry. University College of Medical Sciences & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi 110095, India.
2
Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry. University College of Medical Sciences & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi 110095, India; Department of Pharmacology, University College of Medical Sciences & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi 110095, India
3
Centre for Applied Research in Electronics (CARE), Indian Institute of Technology, Hauz Khas, New Delhi 110016, India
4
Department of Pharmacology, University College of Medical Sciences & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi 110095, India

Abstract

OBJECTIVE:

The present study was designed to investigate the effects of subchronic low level microwave radiation (MWR) on cognitive function, heat shock protein 70 (HSP70) level and DNA damage in brain of Fischer rats.

METHODS:

Experiments were performed on male Fischer rats exposed to microwave radiation for 90 days at three different frequencies: 900, 1800, and 2450 MHz. Animals were divided into 4 groups: Group I: Sham exposed, Group II: animals exposed to microwave radiation at 900 MHz and specific absorption rate (SAR) 5.953 × 10-4 W/kg, Group III: animals exposed to 1800 MHz at SAR 5.835 × 10-4 W/kg and Group IV: animals exposed to 2450 MHz at SAR 6.672 × 10-4 W/kg. All the animals were tested for cognitive function using elevated plus maze and Morris water maze at the end of the exposure period and subsequently sacrificed to collect brain tissues. HSP70 levels were estimated by ELISA and DNA damage was assessed using alkaline comet assay.

RESULTS:

Microwave exposure at 900-2450 MHz with SAR values as mentioned above lead to decline in cognitive function, increase in HSP70 level and DNA damage in brain.

CONCLUSION:

The results of the present study suggest that low level microwave exposure at frequencies 900, 1800, and 2450 MHz may lead to hazardous effects on brain.

KEYWORDS:

Brain; Cognitive function; Comet assay; DNA damage; HSP70; Microwave radiation

PMID:
28081746
DOI:
10.3967/bes2016.115
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Chinese Center for Disease Control and Prevention
Loading ...
Support Center