Chemical pharmacotherapy options for managing adult acne

Expert Opin Pharmacother. 2017 Feb;18(3):263-273. doi: 10.1080/14656566.2017.1282460. Epub 2017 Jan 23.

Abstract

The incidence of adult acne is increasing worldwide. Despite clinical overlap with conventional acne, it has distinct features. Areas covered: A literature search of English-language review articles, randomized control studies and retrospective studies conducted over the past 30 years was performed using PubMed and Google Scholar. Search terms included acne, adult, topical medication, oral medication and skin of color. We highlight important clinical features and treatment modalities pertinent to the evaluation and management of adult acne. Given the relative dearth of literature detailing treatment options specific to adult acne, we offer expert opinion regarding management of the condition especially in special populations such as skin of color and pregnancy. Expert Opinion: It is unclear whether adult acne represents a distinct entity or a continuum of adolescent disease. Providers may opt to use topical medication as first-line, but should have a low threshold for switching to systemic therapy given the magnitude of psychosocial and emotional burden associated with the condition.

Keywords: Acne vulgaris; adult-onset; general dermatology; late-onset; pharmacotherapy; treatment.

Publication types

  • Review

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / etiology
  • Acne Vulgaris / microbiology
  • Acne Vulgaris / psychology
  • Administration, Cutaneous
  • Administration, Oral
  • Adult
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Contraceptives, Oral, Combined / administration & dosage
  • Contraceptives, Oral, Combined / therapeutic use*
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / therapeutic use*
  • Humans
  • Quality of Life
  • Randomized Controlled Trials as Topic
  • Skin / drug effects*
  • Skin / radiation effects
  • Treatment Outcome
  • Ultraviolet Therapy

Substances

  • Anti-Bacterial Agents
  • Contraceptives, Oral, Combined
  • Dermatologic Agents

Supplementary concepts

  • Acne, Adult