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Planta Med. 2017 Aug;83(12-13):1044-1052. doi: 10.1055/s-0042-124493. Epub 2017 Jan 12.

Biosynthetic Studies on Acetosellin and Structure Elucidation of a New Acetosellin Derivative.

Author information

1
Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
2
Biomedical Engineering, Pamukkale University, Denizli, Turkey.
3
Pharmaceutical Chemistry I, University of Bonn, Bonn, Germany.
4
Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), Pharmaceutical Microbiology Unit, University of Bonn, Bonn, Germany.

Abstract

Natural products from fungi, especially Ascomycota, play a major role in therapy and drug discovery. Fungal strains originating from marine habitats offer a new avenue for finding unusual molecular skeletons. Here, the marine-derived fungus Epicoccum nigrum (strain 749) was found to produce the azaphilonoid compounds acetosellin and 5',6'-dihydroxyacetosellin. The latter is a new natural product. The biosynthesis of these polyketide-type compounds is intriguing, since two polyketide chains are assembled to the final product. Here we performed 13C labeling studies on solid cultures to prove this hypothesis for acetosellin biosynthesis.

PMID:
28081580
DOI:
10.1055/s-0042-124493
[Indexed for MEDLINE]

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