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Adv Healthc Mater. 2017 Mar;6(5). doi: 10.1002/adhm.201600549. Epub 2017 Jan 12.

Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model.

Author information

1
Department of Bioengineering, Rice University, Houston, TX 77005, USA.
2
Division of Congenital Heart Surgery, Texas Children's Hospital, Houston, TX 77030, USA.
3
Department of Basic Radiology Research, Texas Children's Hospital, Houston, TX 77030, USA.
4
Department of Molecular Physiology, Baylor College of Medicine, Houston, TX 77030, USA.
5
Department of Bioengineering, University of Colorado Denver/Anschutz Medical Campus, Aurora, CO 80045, USA.

Abstract

In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch.

KEYWORDS:

chitosan; congenital heart defects; heart patch; polycaprolactone; right ventricular outflow tract

PMID:
28081298
PMCID:
PMC5896558
DOI:
10.1002/adhm.201600549
[Indexed for MEDLINE]
Free PMC Article

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