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Philos Trans R Soc Lond B Biol Sci. 2016 Nov 19;371(1708). pii: 20160004. doi: 10.1098/rstb.2016.0004. Epub 2016 Oct 10.

Is the cardiac monitoring function related to the self in both the default network and right anterior insula?

Author information

1
Laboratoire de Neurosciences Cognitives (ENS - INSERM U960), Département d'Etudes Cognitives, Ecole Normale Supérieure - PSL Research University, 75005 Paris, France mariana.babo-rebelo@ens.fr.
2
Laboratoire de Neurosciences Cognitives (ENS - INSERM U960), Département d'Etudes Cognitives, Ecole Normale Supérieure - PSL Research University, 75005 Paris, France.
3
AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Paris 75013, France.

Abstract

The self has been proposed to be rooted in the neural monitoring of internal bodily signals and might thus involve interoceptive areas, notably the right anterior insula (rAI). However, studies on the self consistently showed the involvement of midline default network (DN) nodes, without referring to visceral monitoring. Here, we investigate this apparent discrepancy. We previously showed that neural responses to heartbeats in the DN encode two different self-dimensions, the agentive 'I' and the introspective 'Me', in a whole-brain analysis of magnetoencephalography (MEG) data. Here, we confirm and anatomically refine this result with intracranial recordings (intracranial electroencephalography, iEEG). In two patients, we show a parametric modulation of neural responses to heartbeats by the self-relatedness of thoughts, at the single trial level. A region-of-interest analysis of the insula reveals that MEG responses to heartbeats in the rAI encode the 'I' self-dimension. The effect in rAI was weaker than in the DN and was replicated in iEEG data in one patient out of two. We propose that a common mechanism, the neural monitoring of cardiac signals, underlies the self in both the DN and rAI. This might reconcile studies on the self highlighting the DN, with studies on interoception focusing on the insula.This article is part of the themed issue 'Interoception beyond homeostasis: affect, cognition and mental health'.

KEYWORDS:

heartbeat-evoked responses; interoception; intracranial electroencephalography; magnetoencephalography; neural responses to heartbeats; spontaneous cognition

PMID:
28080963
PMCID:
PMC5062094
DOI:
10.1098/rstb.2016.0004
[Indexed for MEDLINE]
Free PMC Article

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