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Sarcoidosis Vasc Diffuse Lung Dis. 2016 Dec 23;33(4):372-380.

Role of serial F-18 FDG PET/CT scans in assessing treatment response and predicting relapses in patients with symptomatic sarcoidosis.

Author information

1
Senior Resident Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER). arjunjipmer@yahoo.co.in.

Abstract

ackground: Monitoring disease activity in sarcoidosis remains a clinical challenge as there is no gold standard. Positron emission tomography (PET) imaging is a novel tool to assess the metabolic activity. There is limited data on the role of serial PET scans in monitoring the disease activity.

METHODS:

This is a prospective study of 27 sarcoidosis patients treated with systemic corticosteroids. Patients underwent two serial PET/CT scans: one before initiating therapy and the follow up scan at end of therapy. The metabolic response on PET scan was classified as: (a) complete metabolic response (CMR); (b) partial metabolic response (PMR); (c) stable metabolic disease (SMD); and, (d) progressive metabolic disease (PMD). Patients with either CMR or PMR were classified as PET responders while those with SMD or PMD were considered as PET non-responders. All patients were followed at 3, 6 and 12 months after completion of therapy. Relapse rates and relapse-free survival was compared between the various groups.

RESULTS:

There was significant decline in the median SUVmax of the mediastinal lymph nodes, peripheral lymph nodes and the lung parenchyma in the follow up PET scan. Eight patients achieved CMR, 6 patients achieved PMR while 13 patients were PET non-responders. There was no difference in the clinical remission rates between the responders and non-responders. However, the relapse rate was significantly higher in non-responders vs. responders (61.5% vs. 14.2%, p=0.018). None of the patients who achieved a CMR relapsed during the study period.

CONCLUSIONS:

Patients with metabolic response on PET scan have significantly fewer relapses as compared to those with no response on PET scan.

KEYWORDS:

Sarcoidosis; metabolic activity; positron emission tomography; predicting relapse.; response assessment

PMID:
28079849
[Indexed for MEDLINE]

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