Format

Send to

Choose Destination
Anesth Analg. 2017 Apr;124(4):1237-1243. doi: 10.1213/ANE.0000000000001856.

In Vogue: Ketamine for Neuroprotection in Acute Neurologic Injury.

Author information

1
From the Department of Anesthesiology, University of Toronto, Toronto, Ontario, Canada.

Abstract

Neurologic deterioration following acute injury to the central nervous system may be amenable to pharmacologic intervention, although, to date, no such therapy exists. Ketamine is an anesthetic and analgesic emerging as a novel therapy for a number of clinical entities in recent years, including refractory pain, depression, and drug-induced hyperalgesia due to newly discovered mechanisms of action and new application of its known pharmacodynamics. In this focused review, the evidence for ketamine as a neuroprotective agent in stroke, neurotrauma, subarachnoid hemorrhage, and status epilepticus is highlighted, with a focus on its applications for excitotoxicity, neuroinflammation, and neuronal hyperexcitability. Preclinical modeling and clinical applications are discussed.

PMID:
28079589
DOI:
10.1213/ANE.0000000000001856
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center