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Angew Chem Int Ed Engl. 2017 Feb 6;56(7):1873-1876. doi: 10.1002/anie.201610426. Epub 2017 Jan 12.

Ligand-Enabled Alkynylation of C(sp3 )-H Bonds with Palladium(II) Catalysts.

Author information

1
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.

Abstract

The palladium(II)-catalyzed β- and γ-alkynylation of amide C(sp3 )-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing α-tertiary or α-quaternary carbon centers. The β-methylene C(sp3 )-H bonds of various carbocyclic rings were also successfully alkynylated.

KEYWORDS:

C−H activation; alkynylation; amino acids; palladium; pyridine

PMID:
28078773
PMCID:
PMC5512278
DOI:
10.1002/anie.201610426
[Indexed for MEDLINE]
Free PMC Article

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