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Abdom Radiol (NY). 2017 Feb;42(2):351-360. doi: 10.1007/s00261-016-1034-y.

Celiac disease: a clinical review.

Author information

1
Division of Gastroenterology & Hepatology, Mayo Clinic, 200 First Street, S.W., Rochester, MN, 55905, USA. albawardy.badr@mayo.edu.
2
Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
3
Division of Gastroenterology & Hepatology, Mayo Clinic, 200 First Street, S.W., Rochester, MN, 55905, USA.

Abstract

Celiac disease (CD) is an immune-mediated inflammatory enteropathy triggered by gluten exposure in genetically susceptible individuals. It has a high prevalence approaching 1% of the US population. A high index of suspicion is warranted to diagnose CD as frequently patients present with extraintestinal or atypical manifestations. CD is diagnosed by a combination of serum serologies and duodenal biopsies. The majority of patients will respond to a lifelong gluten-free diet which is the cornerstone of therapy. Complications such as refractory CD, ulcerative jejunoileitis, enteropathy associated T-cell lymphoma and small bowel adenocarcinoma occur in a minority of patients.

KEYWORDS:

Celiac disease; Enteropathy; Gluten free; Refractory; Sprue; imaging

PMID:
28078381
DOI:
10.1007/s00261-016-1034-y
[Indexed for MEDLINE]

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