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Prev Nutr Food Sci. 2016 Dec;21(4):384-388. doi: 10.3746/pnf.2016.21.4.384. Epub 2016 Dec 31.

Cytotoxic Effects of Strawberry, Korean Raspberry, and Mulberry Extracts on Human Ovarian Cancer A2780 Cells.

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Department of Food Science, Gyeongnam National University of Science and Technology, Gyeongnam 52725, Korea.
College of Korean Medicine, Gachon University, Gyeonggi 13120, Korea.
Department of Integrative Plant Science, Chung-Ang University, Gyeonggi 17546, Korea.
Department of Food Science and Nutrition, Pusan National University, Busan 46241, Korea.


Reactive oxygen species are tumorigenic by their ability to increase cell proliferation, survival, and cellular migration. The purpose of the present study was to compare the antioxidant activity and cytotoxic effects of 3 berry extracts (strawberry, Korean raspberry, and mulberry) in A2780 human ovarian carcinoma cells. Except for raspberry, the ethyl acetate or methylene chloride fractions of berries containing phenolic compounds exerted dose dependent free radical scavenging activities. In the raspberry fractions, the hexane fraction also exhibited potent antioxidant activity. The cytotoxic effects of berries extracts in A2780 human ovarian carcinoma cells were measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Surprisingly, co-treatment with n-butanol (BuOH) fractions of berries showed stronger cytotoxic effects compared to the other fractions. These findings suggest that potent anticancer molecules are found in the BuOH fractions of berries that have stronger cytotoxic activity than antioxidants.


antioxidant; berry; cytotoxic effect; ovarian cancer

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