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Acta Cir Bras. 2016 Dec;31(12):826-833. doi: 10.1590/S0102-865020160120000008.

Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats.

Author information

1
Fellow PhD degree, Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte (UFRN), Natal-RN, Brazil. Acquisition and interpretation of data, technical procedures, manuscript preparation.
2
Full Professor, Department of Pharmacy, UFRN, Natal-RN, Brazil. CNPq/PQ.1D fellowship. Analysis and interpretation of data, technical procedures, critical revision.
3
Full Professor, Chairman, Nucleus of Experimental Surgery, UFRN, Natal-RN, Brazil. CNPq/PQ.2 fellowship. Conception, design, intellectual and scientific content of the study; analysis and interpretation of data; critical revision.

Abstract

PURPOSE::

To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats.

METHODS::

Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl; 3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i.v.; 4) normal coconut water. At 8h post-resuscitation, blood and lungs were collected for exams.

RESULTS::

Clinical scores, TNF-α, IL-1β, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments.

CONCLUSIONS::

Resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score.

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