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Adv Healthc Mater. 2017 Jan;6(1). doi: 10.1002/adhm.201600750. Epub 2016 Nov 7.

Ebola Vaccination Using a DNA Vaccine Coated on PLGA-PLL/γPGA Nanoparticles Administered Using a Microneedle Patch.

Author information

1
Institute of Medical Science and Technology, National Sun Yat-sen University, 70 Lienhai Rd., Kaohsiung, 80424, Taiwan, R.O.C.
2
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332, USA.
3
Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1648 Pierce Drive, Atlanta, GA, 30322, USA.
4
College of Materials Science and Engineering, Beijing University of Chemical Technology, 15 Beisanhuandong Road, Chaoyang District, Beijing, China.

Abstract

Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.

KEYWORDS:

Ebola DNA vaccine; cationic nanoparticles; indradermal vaccine delivery; microneedle patch; minimally invasive skin vaccination

PMID:
28075069
DOI:
10.1002/adhm.201600750
[Indexed for MEDLINE]

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