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Muscle Nerve. 2017 Dec;56(6):1143-1148. doi: 10.1002/mus.25571. Epub 2017 Mar 17.

Does partial muscle reinnervation preserve future re-innervation potential?

Author information

1
Division of Hand Surgery, Department of Orthopaedic Surgery, Virginia Commonwealth University Medical Center, 1200 East Broad Street, Richmond, Virginia, 23298, USA.
2
Department of Physical Therapy, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA.

Abstract

INTRODUCTION:

Late revision nerve surgery for incomplete motor recovery due to partial reinnervation would improve muscle function if all muscle fibers were protected from developing denervation atrophy.

METHODS:

Sixty immature Sprague-Dawley rats underwent the following tibial nerve manipulations (n = 15/group): group A, partial denervation (two thirds of nerve resected and the remaining one third crushed), revision repair at 8 months; group B, partial denervation; group C, complete denervation, immediate reconstruction; group D, complete denervation, reconstruction at 8 months; and group E, control. Final testing at 11 months included muscle force, weight, and histology.

RESULTS:

Muscle weight was significantly (P < 0.05) different among all groups (highest to lowest: E > B > C > A > D), and force was significantly lower in groups A and D compared with E. Muscle fiber cross-sectional area was statistically smaller in group A than in groups B, C, or E.

DISCUSSION:

Partial reinnervation still allowed substantial muscle recovery, but it did not preserve the non-innervated muscle fibers. Muscle Nerve 56: 1143-1148, 2017.

KEYWORDS:

atrophy; denervation; muscle histology; partial nerve injury; revision nerve repair; rodent

PMID:
28073145
PMCID:
PMC5503806
DOI:
10.1002/mus.25571
[Indexed for MEDLINE]
Free PMC Article

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