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Funct Neurol. 2016 Oct/Dec;31(4):217-228.

Modeling white matter microstructure.

Abstract

Quantitative magnetic resonance imaging can be combined with advanced biophysical models to measure microstructural features of white matter. Non-invasive microstructural imaging has the potential to revolutionize neuroscience, and acquiring these measures in clinically feasible times would greatly improve patient monitoring and clinical studies of drug efficacy. However, a good understanding of microstructural imaging techniques is essential to set realistic expectations and to prevent over-interpretation of results. This review explains the methodology behind microstructural modeling and imaging, and gives an overview of the breakthroughs and challenges associated with it.

PMID:
28072382
PMCID:
PMC5231884
[Indexed for MEDLINE]
Free PMC Article

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