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Indian J Cancer. 2016 Apr-Jun;53(2):304-308. doi: 10.4103/0019-509X.197723.

Place of birth and risk of gallbladder cancer in India.

Author information

1
Centre for Cancer Epidemiology, Tata Memorial Centre, Mumbai, Maharashtra, India.
2
Chiplunkar Lab, Advanced Center for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.
3
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
4
Department of Digestive Diseases and Clinical Nutrition, Tata Memorial Hospital, Mumbai, Maharashtra, India.
5
Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.
6
Centre for Global Health, National Cancer Institute, NIH, DHSS, Bethesda, USA.

Abstract

CONTEXT:

Within India, the incidence of gallbladder cancer (GBC) is characterized by marked geographical variation; however, the reasons for these differences are unclear.

AIMS:

To evaluate the role of place of birth, length of residence, and effect of migration from high- to low-risk region on GBC development.

SETTINGS AND DESIGN:

Population-based cancer registries (PBCRs); case-control study.

SUBJECTS AND METHODS:

Data of PBCRs were used to demonstrate geographical variation in GBC incidence rates. A case-control study data examined the role of birth place, residence length, and effect of migration in etiology of GBC.

STATISTICAL ANALYSIS:

Rate ratios for different PBCRs were estimated using Chennai Cancer Registry as the reference population. Odds ratios (ORs) for developing GBC in a high-risk region compared to a low-risk region and associated 95% confidence interval (CI) were estimated through unconditional logistic regression models using case-control study.

RESULTS:

GBC shows marked variation in incidence with risk highest in Northeast regions and lowest in South India. OR of 4.82 (95% CI: 3.87-5.99) was observed for developing GBC for individuals born in a high-risk region compared to those born in a low-risk region after adjusting for confounders. A dose-response relationship with increased risk with increased length of residence in a high-risk region was observed (OR lifetime 5.58 [95% CI: 4.42-7.05]; Ptrend ≤ 0.001). The risk persisted even if study participant migrated from high- to low-risk region (OR = 1.36; 95% CI: 1.02-1.82).

CONCLUSIONS:

The present study signifies the importance of place of birth, length of stay, and effect of migration from high- to low-risk region in the development of GBC. The data indicate role of environmental and genetic factors in etiology of disease.

PMID:
28071634
DOI:
10.4103/0019-509X.197723
[Indexed for MEDLINE]
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