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Eur J Nutr. 2018 Mar;57(2):689-701. doi: 10.1007/s00394-016-1356-0. Epub 2016 Dec 22.

Red and processed meat consumption and risk of bladder cancer: a dose-response meta-analysis of epidemiological studies.

Author information

1
Public Health Sciences, Karolinska Institutet, Tomtebodavagen 18A, 171 77, Stockholm, Sweden. alessio.crippa@ki.se.
2
Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels Vag 13, 171 77, Stockholm, Sweden.
3
Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Nobels Vag 13, 171 77, Stockholm, Sweden.
4
Public Health Sciences, Karolinska Institutet, Tomtebodavagen 18A, 171 77, Stockholm, Sweden.

Abstract

BACKGROUND/OBJECTIVES:

Several epidemiological studies have analyzed the associations between red and processed meat and bladder cancer risk but the shape and strength of the associations are still unclear. Therefore, we conducted a dose-response meta-analysis to quantify the potential association between red and processed meat and bladder cancer risk.

METHODS:

Relevant studies were identified by searching the PubMed database through January 2016 and reviewing the reference lists of the retrieved articles. Results were combined using random-effects models.

RESULTS:

Five cohort studies with 3262 cases and 1,038,787 participants and 8 cases-control studies with 7009 cases and 27,240 participants met the inclusion criteria. Red meat was linearly associated with bladder cancer risk in case-control studies, with a pooled RR of 1.51 (95% confidence interval (CI) 1.13, 2.02) for every 100 g increase per day, while no association was observed among cohort studies (P heterogeneity across study design = 0.02). Based on both case-control and cohort studies, the pooled relative risk (RR) for every 50 g increase of processed meat per day was 1.20 (95% CI 1.06, 1.37) (P heterogeneity across study design = 0.22).

CONCLUSIONS:

This meta-analysis suggests that processed meat may be positively associated with bladder cancer risk. A positive association between red meat and risk of bladder cancer was observed only in case-control studies, while no association was observe in prospective studies.

KEYWORDS:

Bladder cancer; Dose–response; Meta-analysis; Processed meat; Red meat

PMID:
28070638
PMCID:
PMC5845591
DOI:
10.1007/s00394-016-1356-0
[Indexed for MEDLINE]
Free PMC Article

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