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Food Sci Nutr. 2016 Apr 25;5(1):148-159. doi: 10.1002/fsn3.374. eCollection 2017 Jan.

Effects of cranberry extracts on gene expression in THP-1 cells.

Author information

1
Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis Penn State University 325 Life Sciences Building University Park Pennsylvania 16802.
2
Ocean Spray Cranberries, Inc. One Ocean Spray Drive Lakeville-Middleboro Massachusetts 02349.
3
UnitedBio-Med Inc. 102 Hunters Run Dobbs Ferry New York 10502.
4
Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis Penn State University 325 Life Sciences Building University Park Pennsylvania 16802; INDIGO Biosciences Inc.1981 Pine Hall Road State College Pennsylvania 16801.

Abstract

Cranberry contains high levels of nutrients and bioactive molecules that have health-promoting properties. The purpose of the present studies was to determine if cranberry extracts (CEs) contain phytochemicals that exert anti-inflammatory effects. The human monocytic cell line THP-1 was treated with two CEs (CE and 90MX) and subsequently challenged with Lipopolysaccharides (LPS). Tumor necrosis factor α (TNF α) expression was decreased in the CE-treated cells, indicative of an anti-inflammatory effect. Gene expression microarrays identified several immune-related genes that were responsive to CEs including interferon-induced protein with tetratricopeptide repeats 1 and 3 (IFIT 1 and 3), macrophage scavenger receptor 1 (MSR1) and colony-stimulating factor 2 (CSF2). In addition, in the CE-treated cells, metallothionein 1F and other metal-responsive genes were induced. Taken together, this data indicates that CEs contain bioactive components that have anti-inflammatory effects and may protect cells from oxidative damage.

KEYWORDS:

Gene expression; macrophage; nutrigenomics; proanthocyanidins; reactive oxygen species

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