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Am J Chin Med. 2017;45(1):13-22. doi: 10.1142/S0192415X17500021. Epub 2017 Jan 9.

Ginseng on Cancer: Potential Role in Modulating Inflammation-Mediated Angiogenesis.

Dai D1,2, Zhang CF1,2, Williams S1,2, Yuan CS1,2,3, Wang CZ1,2.

Author information

1
* Tang Center for Herbal Medicine Research, Pritzker School of Medicine, USA.
2
† Department of Anesthesia & Critical Care, Pritzker School of Medicine, USA.
3
‡ Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL 60637, USA.

Abstract

Angiogenesis is a regulated process integral to many physiological and pathological situations, including carcinogenesis and tumor growth. The majority of the angiogenic processes are related to inflammation. The interplay is not only important in the case of pathogen entry but also influential in chronic inflammatory diseases, tumor growth and tissue regeneration. Modulating the interaction between inflammation and angiogenesis could be an important target for cancer treatment and wound healing alike. Ginseng has a wide range of pharmacological effects, including anti-inflammatory and angiogenesis-modulating activities. This paper presents the recent research progresses on the inhibition of angiogenesis by ginseng and its active constituents, with a particular focus on processes mediated by inflammation. The modulatory role of ginseng compounds in inflammation-mediated angiogenesis involving hypoxia and microRNAs are also discussed. With the potential to modulate the angiogenesis at the transcriptional, translational and protein signaling level via various different mechanisms, ginseng could prove to be effective in cancer therapeutics.

KEYWORDS:

Angiogenesis; Cancer Therapeutics; Ginseng; Ginsenoside; Hypoxia; Inflammation; Metabolite; MicroRNA; Review

PMID:
28068835
DOI:
10.1142/S0192415X17500021
[Indexed for MEDLINE]

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