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ACS Chem Biol. 2017 Mar 17;12(3):586-600. doi: 10.1021/acschembio.6b01148. Epub 2017 Jan 30.

Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology.

Author information

1
Department of Chemistry & Chemical Biology, Cornell University , Ithaca, New York 14850, United States.
2
Department of Biochemistry, Weill Cornell Medicine , New York, New York 10065, United States.

Abstract

Networks of redox sensor proteins within discrete microdomains regulate the flow of redox signaling. Yet, the inherent reactivity of redox signals complicates the study of specific redox events and pathways by traditional methods. Herein, we review designer chemistries capable of measuring flux and/or mimicking subcellular redox signaling at the cellular and organismal level. Such efforts have begun to decipher the logic underlying organelle-, site-, and target-specific redox signaling in vitro and in vivo. These data highlight chemical biology as a perfect gateway to interrogate how nature choreographs subcellular redox chemistry to drive precision redox biology.

PMID:
28068059
PMCID:
PMC5592730
DOI:
10.1021/acschembio.6b01148
[Indexed for MEDLINE]
Free PMC Article

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