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Insects. 2017 Jan 5;8(1). pii: E4. doi: 10.3390/insects8010004.

RNA Interference for Mosquito and Mosquito-Borne Disease Control.

Author information

1
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA. airs@wisc.edu.
2
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA. lbartholomay@wisc.edu.

Abstract

RNA interference (RNAi) is a powerful tool to silence endogenous mosquito and mosquito-borne pathogen genes in vivo. As the number of studies utilizing RNAi in basic research grows, so too does the arsenal of physiological targets that can be developed into products that interrupt mosquito life cycles and behaviors and, thereby, relieve the burden of mosquitoes on human health and well-being. As this technology becomes more viable for use in beneficial and pest insect management in agricultural settings, it is exciting to consider its role in public health entomology. Existing and burgeoning strategies for insecticide delivery could be adapted to function as RNAi trigger delivery systems and thereby expedite transformation of RNAi from the lab to the field for mosquito control. Taken together, development of RNAi-based vector and pathogen management techniques & strategies are within reach. That said, tools for successful RNAi design, studies exploring RNAi in the context of vector control, and studies demonstrating field efficacy of RNAi trigger delivery have yet to be honed and/or developed for mosquito control.

KEYWORDS:

Aedes aegypti; Anopheles gambiae; RNA interference; RNAi; mosquito control; vector control

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