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Chem Commun (Camb). 2017 Jan 19;53(7):1261-1264. doi: 10.1039/c6cc09323j.

Ruthenium-catalyzed meta/ortho-selective C-H alkylation of azoarenes using alkyl bromides.

Author information

1
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455002, P. R. China. lgorgchem@126.com yang_suling@163.com and Henan Province Key Laboratory of New Optoelectronic Functional Materials, Anyang Normal University, Anyang 455002, P. R. China.

Abstract

meta/ortho-Selective CAr-H (di)alkylation reactions of azoarenes have been achieved via [Ru(p-cymene)Cl2]2 catalyzed ortho-metalation using various types of alkyl bromides. Particularly, dual meta-alkylation of azoarene and reduction offer an attractive strategy for the synthesis of meta-alkylanilines, which are difficult to access via traditional aniline functionalization methods.

PMID:
28067355
DOI:
10.1039/c6cc09323j

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