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Sci Rep. 2017 Jan 9;7:40401. doi: 10.1038/srep40401.

Stromal Cell Subsets Directing Neonatal Spleen Regeneration.

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AK Project, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Division of Biomedical Science, Research School of Biology, The Australian National University, Canberra 0200, Australia.


Development of lymphoid tissue is determined by interactions between stromal lymphoid tissue organiser (LTo) and hematopoietic lymphoid tissue inducer (LTi) cells. A failure for LTo to receive appropriate activating signals during embryogenesis through lymphotoxin engagement leads to a complete cessation of lymph node (LN) and Peyer's patch development, identifying LTo as a key stromal population for lymphoid tissue organogenesis. However, little is known about the equivalent stromal cells that induce spleen development. Here, by dissociating neonatal murine spleen stromal tissue for re-aggregation and transplant into adult mouse recipients, we have identified a MAdCAM-1+CD31+CD201+ spleen stromal organizer cell-type critical for new tissue formation. This finding provides an insight into the regulation of post-natal spleen tissue organogenesis, and could be exploited in the development of spleen regenerative therapies.

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