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Bioorg Med Chem Lett. 2017 Feb 1;27(3):387-392. doi: 10.1016/j.bmcl.2016.12.068. Epub 2016 Dec 29.

Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents.

Author information

1
Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States.
2
Department of Biological Sciences, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States.
3
Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, United States. Electronic address: malam@astate.edu.

Abstract

Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the world is moving toward a post-antibiotic era, in which normal infections or minor injuries may become fatal. In an effort to find new agents, we report the synthesis and antimicrobial activities of 40 novel 1,3-diphenyl pyrazole derivatives. These compounds have shown zones of growth inhibition up to 85mm against Acinetobacter baumannii. We tested the active compounds against this Gram-negative bacterium in minimum inhibitory concentration (MIC) tests and found activity with concentration as low as 4μg/mL.

KEYWORDS:

Acinetobacter baumannii; Antibacterial; Antimicrobials; Hydrazone; Methicillin-resistant Staphylococcus aureus (MRSA); Pyrazole; Resistant

PMID:
28065568
PMCID:
PMC5486227
DOI:
10.1016/j.bmcl.2016.12.068
[Indexed for MEDLINE]
Free PMC Article

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