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Cell. 2017 Jan 12;168(1-2):280-294.e12. doi: 10.1016/j.cell.2016.12.005. Epub 2017 Jan 5.

Quantitative Predictions Orchestrate Visual Signaling in Drosophila.

Author information

1
Laboratory of Integrative Brain Function, The Rockefeller University, New York, NY 10065, USA.
2
Laboratory of Integrative Brain Function, The Rockefeller University, New York, NY 10065, USA. Electronic address: maimon@rockefeller.edu.

Abstract

Vision influences behavior, but ongoing behavior also modulates vision in animals ranging from insects to primates. The function and biophysical mechanisms of most such modulations remain unresolved. Here, we combine behavioral genetics, electrophysiology, and high-speed videography to advance a function for behavioral modulations of visual processing in Drosophila. We argue that a set of motion-sensitive visual neurons regulate gaze-stabilizing head movements. We describe how, during flight turns, Drosophila perform a set of head movements that require silencing their gaze-stability reflexes along the primary rotation axis of the turn. Consistent with this behavioral requirement, we find pervasive motor-related inputs to the visual neurons, which quantitatively silence their predicted visual responses to rotations around the relevant axis while preserving sensitivity around other axes. This work proposes a function for a behavioral modulation of visual processing and illustrates how the brain can remove one sensory signal from a circuit carrying multiple related signals.

KEYWORDS:

Drosophila; action initiation; corollary discharge; efference copy; electrophysiology; eye movements; neural circuits; patch-clamp; vision; visuomotor processing

PMID:
28065412
PMCID:
PMC6320683
DOI:
10.1016/j.cell.2016.12.005
[Indexed for MEDLINE]
Free PMC Article

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