Format

Send to

Choose Destination
Fertil Steril. 2017 Mar;107(3):749-755. doi: 10.1016/j.fertnstert.2016.11.022. Epub 2017 Jan 5.

Prospective evaluation of luteal phase length and natural fertility.

Author information

1
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: nmcraw@gmail.com.
2
Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina.
3
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.

Abstract

OBJECTIVE:

To evaluate the impact of a short luteal phase on fecundity.

DESIGN:

Prospective time-to-pregnancy cohort study.

SETTING:

Not applicable.

PATIENT(S):

Women trying to conceive, ages 30-44 years, without known infertility.

INTERVENTION(S):

Daily diaries, ovulation prediction testing, standardized pregnancy testing.

MAIN OUTCOME MEASURE(S):

Subsequent cycle fecundity.

RESULT(S):

Included in the analysis were 1,635 cycles from 284 women. A short luteal phase (≤11 days including the day of ovulation) occurred in 18% of observed cycles. Mean luteal phase length was 14 days. Significantly more women with a short luteal phase were smokers. After adjustment for age, women with a short luteal phase had 0.82 times the odds of pregnancy in the subsequent cycle immediately following the short luteal phase compared with women without a short luteal phase. Women with a short luteal length in the first observed cycle had significantly lower fertility after the first 6 months of pregnancy attempt, but at 12 months there was no significant difference in cumulative probability of pregnancy.

CONCLUSION(S):

Although an isolated cycle with a short luteal phase may negatively affect short-term fertility, incidence of infertility at 12 months was not significantly higher among these women.

CLINICAL TRIAL REGISTRATION NUMBER:

NCT01028365.

KEYWORDS:

Short luteal phase; fecundity; luteal phase deficiency; natural fertility

PMID:
28065408
PMCID:
PMC5337433
DOI:
10.1016/j.fertnstert.2016.11.022
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center