[Effect of fenibut and seduxen on fetal development in the second half of pregnancy]

Farmakol Toksikol. 1989 Jul-Aug;52(4):37-9.
[Article in Russian]

Abstract

In experiments on rats it was found that fenibut (50 mg/kg, 1/20 of LD50) during a single and repeated administration in the fetus period of pregnancy does not exert any negative effect on the maternal organism, the growth and development of the fetus. Seduxen administered in a dose of 50 mg/kg (1/80 of LD50) alone and in combination with fenibut was shown to decrease the female body weight gain and to disturb the fetus development. Following a single administration on the 17th day of pregnancy, the effect was poorly pronounced.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Diazepam / adverse effects*
  • Embryonic and Fetal Development / drug effects*
  • Female
  • Gestational Age
  • Osteogenesis / drug effects
  • Pregnancy
  • Pregnancy, Animal / drug effects*
  • Rats
  • Tranquilizing Agents / adverse effects*
  • gamma-Aminobutyric Acid / adverse effects
  • gamma-Aminobutyric Acid / analogs & derivatives*

Substances

  • Tranquilizing Agents
  • gamma-Aminobutyric Acid
  • Diazepam
  • 4-amino-3-phenylbutyric acid