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Farmakol Toksikol. 1989 Jul-Aug;52(4):14-7.

[Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze].

[Article in Russian]


During four weeks rats were learned to visit consequently 4 baited arms in the 8-armed radial maze. Picamilone (nicotinoyl-GABA) in a dose of 10 mg/kg daily accelerated rats to reach 80% level of learning (to 20-28 trials). After picamilone injections rats obtained the maximal level of short-term memory as just 3-5 trials. Piracetam in a dose of 200 mg/kg daily exerted no effects on long-term and short-term memory of rats in the radial maze.

[Indexed for MEDLINE]

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