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World J Mens Health. 2017 Apr;35(1):43-50. doi: 10.5534/wjmh.2017.35.1.43. Epub 2016 Dec 22.

Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model.

Author information

1
Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
2
Catholic Integrative Medicine Research Institute, The Catholic University of Korea, Seoul, Korea.
3
Biomix Inc., Goyang, Korea.
4
Catholic Integrative Medicine Research Institute, The Catholic University of Korea, Seoul, Korea. ksw1227@catholic.ac.kr.

Abstract

PURPOSE:

This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats.

MATERIALS AND METHODS:

Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each: a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined.

RESULTS:

Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis.

CONCLUSIONS:

Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.

KEYWORDS:

Antioxidants; Erectile dysfunction; Testosterone

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