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Trends Endocrinol Metab. 2017 Apr;28(4):297-308. doi: 10.1016/j.tem.2016.12.003. Epub 2017 Jan 4.

Peroxisomal Dysfunction in Age-Related Diseases.

Author information

1
Division of Endocrinology, Metabolism & Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
2
Division of Endocrinology, Metabolism & Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: ilodhi@wustl.edu.

Abstract

Peroxisomes carry out many key functions related to lipid and reactive oxygen species (ROS) metabolism. The fundamental importance of peroxisomes for health in humans is underscored by the existence of devastating genetic disorders caused by impaired peroxisomal function or lack of peroxisomes. Emerging studies suggest that peroxisomal function may also be altered with aging and contribute to the pathogenesis of a variety of diseases, including diabetes and its related complications, neurodegenerative disorders, and cancer. With increasing evidence connecting peroxisomal dysfunction to the pathogenesis of these acquired diseases, the possibility of targeting peroxisomal function in disease prevention or treatment becomes intriguing. Here, we review recent developments in understanding the pathophysiological implications of peroxisomal dysfunctions outside the context of inherited peroxisomal disorders.

KEYWORDS:

aging; neurodegeneration; peroxisome; pexophagy; reactive oxygen species

PMID:
28063767
PMCID:
PMC5366081
DOI:
10.1016/j.tem.2016.12.003
[Indexed for MEDLINE]
Free PMC Article

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