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Curr Opin Struct Biol. 2017 Jun;44:59-66. doi: 10.1016/j.sbi.2016.12.009. Epub 2017 Jan 4.

Peptides and peptidomimetics as regulators of protein-protein interactions.

Author information

1
Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA 94305-5174, USA.
2
Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA 94305-5174, USA. Electronic address: nirqvit@stanford.edu.
3
Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA 94305-5174, USA. Electronic address: mochly@stanford.edu.

Abstract

Protein-protein interactions are essential for almost all intracellular and extracellular biological processes. Regulation of protein-protein interactions is one strategy to regulate cell fate in a highly selective manner. Specifically, peptides are ideal candidates for inhibition of protein-protein interactions because they can mimic a protein surface to effectively compete for binding. Additionally, peptides are synthetically accessible and can be stabilized by chemical modifications. In this review, we survey screening and rational design methods for identifying peptides to inhibit protein-protein interactions, as well as methods for stabilizing peptides to effectively mimic protein surfaces. In addition, we discuss recent applications of peptides to regulate protein-protein interactions for both basic research and therapeutic purposes.

PMID:
28063303
PMCID:
PMC5496809
DOI:
10.1016/j.sbi.2016.12.009
[Indexed for MEDLINE]
Free PMC Article

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