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J Headache Pain. 2017 Dec;18(1):2. doi: 10.1186/s10194-016-0712-z. Epub 2017 Jan 6.

Excitability of the motor cortex in patients with migraine changes with the time elapsed from the last attack.

Author information

1
Department of Medico-Surgical Sciences and Biotechnologies, 'Sapienza' University of Rome Polo Pontino, Corso della Repubblica 79, 04100, Latina, Italy. francesca.cortese05@libero.it.
2
G. B. Bietti Foundation IRCCS, Research Unit of Neurophysiology of Vision and Neuro-Ophthalmology, Rome, Italy.
3
Department of Medico-Surgical Sciences and Biotechnologies, 'Sapienza' University of Rome Polo Pontino, Corso della Repubblica 79, 04100, Latina, Italy.
4
Don Carlo Gnocchi, Onlus Foundation, Milan, Italy.
5
INM Neuromed IRCCS, Pozzilli, (IS), Italy.

Abstract

BACKGROUND:

Motor-evoked potentials (MEPs) produced by single-pulse transcranial magnetic stimulation (TMS) of the motor cortex can be an objective measure of cortical excitability. Previously, MEP thresholds were found to be normal, increased, or even reduced in patients with migraine. In the present study, we determined whether the level of cortical excitability changes with the time interval from the last migraine attack, thereby accounting for the inconsistencies in previous reports.

METHODS:

Twenty-six patients with untreated migraine without aura (MO) underwent a MEP study between attacks. Their data were then compared to the MEP data collected from a group of 24 healthy volunteers (HVs). During the experiment, the TMS figure-of-eight coil was positioned over the left motor area. After identifying the resting motor threshold (RMT), we delivered 10 single TMS pulses (rate: 0.1 Hz, intensity: 120% of the RMT) and averaged the resulting MEP amplitudes.

RESULTS:

The mean RMTs and MEP amplitudes were not significantly different between the MO and HV groups. In patients with MO, the RMTs were negatively correlated with the number of days elapsed since the last migraine attack (rho = -0.404, p = 0.04).

CONCLUSION:

Our results suggest that the threshold for evoking MEPs is influenced by the proximity of an attack; specifically, the threshold is lower when a long time interval has passed after an attack, and is higher (within the range of normative values) when measured close to an attack. These dynamic RMT variations resemble those we reported previously for visual and somatosensory evoked potentials and may represent time-dependent plastic changes in brain excitability in relation to the migraine cycle.

KEYWORDS:

Ictal; Interictal; Migraine; Motor threshold; Transcranial magnetic stimulation

PMID:
28063106
PMCID:
PMC5218956
DOI:
10.1186/s10194-016-0712-z
[Indexed for MEDLINE]
Free PMC Article

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