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Breast Cancer Res Treat. 2017 Feb;162(1):139-149. doi: 10.1007/s10549-016-4084-5. Epub 2017 Jan 6.

Body size from birth through adolescence in relation to risk of benign breast disease in young women.

Author information

1
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA. Catherine.Berkey@channing.harvard.edu.
2
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA.
3
Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
4
Department of Obstetrics and Gynaecology, University of Melbourne and The Royal Women's Hospital, Melbourne, Australia.
5
Division of Public Health Sciences, Department of Surgery, Alvin J Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
6
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
7
Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.

Abstract

PURPOSE:

Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk.

METHODS:

The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided pregnancy-related data. From 2005 to 2013, participants (18 year+) reported whether they had ever been diagnosed with biopsy-confirmed BBD (N = 142 cases).

RESULTS:

Girls had greater adiposity (BMI; kg/m2) at 10 year if they were larger at birth, if mother's pre-pregnancy BMI was higher, or if gestational weight gain was greater (all p < .01). Maternal height was (positively) associated (p < .05) with adolescent peak height growth velocity (PHV; in./year). Greater 10 year adiposity was associated with lower PHV and less height growth 10-18 year (both p < .01). Adiposity at 10 year was inversely associated with BBD (OR 0.83/(kg/m2), p < .01) as was increasing adiposity 10-18 year (OR 0.85/(kg/m2), p = .01). In a separate model, 10 year height (OR 1.13/in., p = .02) and height growth 10-18 year (OR 1.19/in.; p < .01) were positively associated. PHV was similarly positively associated (OR 2.58, p = .01, fastest versus slowest growth quartiles). In a multivariable model of BBD risk, gestational weight gain (daughters at highest risk if <20 lb gained), PHV (slowest growing girls at lowest risk), age 10 year height (positive), and BMI (inverse) were the most critical childhood risk factors (each p < .05).

CONCLUSIONS:

Body size factors from pregnancy through adolescence were independently associated with BBD risk in young women.

KEYWORDS:

Birth weight; Childhood adiposity; Gestational weight gain; Height growth; Maternal pre-pregnancy BMI; Prenatal

PMID:
28062981
PMCID:
PMC5290089
DOI:
10.1007/s10549-016-4084-5
[Indexed for MEDLINE]
Free PMC Article

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