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J Pediatric Infect Dis Soc. 2017 Nov 24;6(4):393-398. doi: 10.1093/jpids/piw066.

Neurobrucellosis: Unexpected Answer From Metagenomic Next-Generation Sequencing.

Author information

1
Department of Pediatrics, Division of Infectious Diseases.
2
Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles.
3
Department of Laboratory Medicine.
4
UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California.
5
Department of Pediatrics, Division of Infectious Diseases, University of California, Los Angeles.
6
Department of Medicine, Division of Infectious Diseases, University of California, San Francisco.

Abstract

A diagnosis of brucellosis can be difficult because routine culture and serological methods exhibit variable sensitivity and specificity. We present the use of a metagenomic next- generation sequencing assay to diagnose a case of neurobrucellosis from cerebrospinal fluid, resulting in the institution of appropriate antibiotic treatment and a favorable clinical outcome.

KEYWORDS:

diagnostic microbiology; encephalitis; meningitis; metagenomic next-generation sequencing; neurobrucellosis

PMID:
28062553
PMCID:
PMC6251619
DOI:
10.1093/jpids/piw066
[Indexed for MEDLINE]
Free PMC Article

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