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Oncotarget. 2017 Feb 7;8(6):10485-10497. doi: 10.18632/oncotarget.14441.

A potential prognostic lncRNA signature for predicting survival in patients with bladder urothelial carcinoma.

Author information

1
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.
2
Urology Surgery Department, Affiliated Hospital of Taishan Medical University, Shandong, China.

Abstract

Increasing evidence has highlighted the critical roles of long non-coding RNA (lncRNA) in cancer development and progression. However, the prognostic power of expression-based lncRNA signature for predicting overall survival in patients with Bladder Urothelial Carcinoma (BLCA) has not been investigated. Here, we performed a comprehensive analysis for lncRNA expression profiles and corresponding clinical information of 234 BLCA patients from The Cancer Genome Atlas (TCGA). We established a set of four-lncRNAs that were significantly associated with BLCA patients' survival. Using the prognostic four-lncRNA signature, we successfully classified the BLCA patients into high-risk and low-risk groups, and the prognostic power of the four-lncRNA signature was further validated in the testing dataset and entire dataset. Multivariate Cox regression and stratified analyses demonstrated that the prognostic power of the four-lncRNA signature was independent of other clinical variables. Functional enrichment analyses suggested the four prognostic lncRNAs may be involved in known BLCA-related biological processes and pathways. Our results demonstrated that the four-lncRNA signature could be novel independent biomarkers for predicting survival in patients with BLCA.

KEYWORDS:

bladder urothelial carcinoma; long non-coding RNA; prognosis

PMID:
28060759
PMCID:
PMC5354674
DOI:
10.18632/oncotarget.14441
[Indexed for MEDLINE]
Free PMC Article

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