Format

Send to

Choose Destination
Oncotarget. 2017 Jan 31;8(5):8717-8725. doi: 10.18632/oncotarget.14427.

Influence of EGFR mutational status on metastatic behavior in non squamous non small cell lung cancer.

Author information

1
Medical Oncology Unit A.O. Papardo & Department of Human Pathology University of Messina, Italy.
2
Fondazione Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy.
3
Department of Medicine, Surgery and Neuroscience, University of Siena and Istituto Toscano Tumori (ITT), Siena, Italy.
4
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia PA, USA.

Abstract

Epidermal Growth Factor Receptor (EGFR) mutated Non Small Cell Lung Cancers (NSCLCs) are a molecularly subgroup of patients with peculiar clinic-pathological characteristics. Previous studies have suggested a possible interaction between oncogene status and metastatic behavior in non squamous NSCLCs with conflicting results. The aim of this study was to compare the different metastatic patterns, at baseline and during the course of the disease, in a cohort of 137 Caucasian patients with non-squamous NSCLC according to the EGFR mutational status and survival differences according to the different metastatic behavior. We observed unique metastatic distributions between EGFR-mutated and EGFR wild type non-squamous NSCLCs. These data support the hypothesis that tumor bio-molecular characteristics and genotype may influence the metastatic process in NSCLC and might help the development of enrichment strategies for tumor genotyping in these tumors, especially in the presence of limited tissue availability.

KEYWORDS:

EGFR WT; EGFR mutations; NSCLC; brain metastases; metastatic spread

PMID:
28060728
PMCID:
PMC5352435
DOI:
10.18632/oncotarget.14427
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Impact Journals, LLC Icon for PubMed Central
Loading ...
Support Center